Biology/Screening Service

Key Organics - offers a wide range of biology/screening services to assist in the identification of lead compounds in any therapeutic area

Key Biology

Key Organics offers a wide range of products and services to cater directly for Biologists and Biochemists active in the Pharmaceutical, Agrochemical, Biotechnology, and related sectors.

Bionet Assay Standards

This extensive collection is designed and sourced specifically to satisfy customer demand for small, screening sized quantities of specific assay standards and metabolites for comparison testing and screening, and to support registration / re-registration of compounds including generics.

The Bionet Assay Standards Collection eliminates unnecessary wastage of cumbersome bulk quantities of active ingredients and saves customers' money by providing bespoke mg quantities according to individual requirements rather than a 'standard pack size'. The collection contains a diverse selection of Assay Standards, including APIs, Peptides, Natural Products, Hormones and Metabolites. All are available in screening size quantities for research purposes.

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Screening Compounds

The world renowned Bionet Screening Catalogue currently contains over 42,500 novel compounds with numbers rising rapidly. These compounds have proven biological activity across sectors in pharma, biotech and agro industries. Over 90% of these compounds are unique to Bionet with standard minimum purity of >90%.

Bionet Diversity Sets offer a representative and cost-effective 'taster' of the entire catalogue, to enable targeted follow-up purchase of specific Bionet compounds most closely matching a client's particular areas of interest.

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Fragment Libraries

Key Organics has created the enhanced Bionet Fragment Library Ro3. These compounds will greatly appeal to all discovery scientists in the pharma and agrochemistry sectors.

The Bionet Fragment Library Ro3 encompasses 6,355 carefully selected diverse fragments which have been rigorously chosen for their suitability for fragment based screening applications. There are significant numbers of singletons, illustrating the diversity of the collection. It has been established that 3,228 of these fragments are uniquely available through Bionet based on a comparison with commercially available libraries containing >8 million compounds.

All the fragments obey the 'Rule of three' and both solubility and topological polar surface area (TPSA) descriptors have been calculated.

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Biology/Screening Service

Key Organics offers a wide range of biology / screening services to assist in the identification of lead compounds in any therapeutic area.

These services provide solutions to identify early stage drug candidates in a fast and cost effective process and eliminate compounds that are likely to fail in the later stages. Key Organics can arrange for assay development and implementation of the assays into automated screening processes with dramatically lower consumption of biological targets and test compounds. The follow up confirmation/selectivity profiling service will significantly increase the efficiency in the process of identifying the lead compounds. Combined with in vitro toxicology tests and SAR study, Key Organics' services will shorten the time for preclinical discovery in a very cost effective way.

Key Capabilities:
• Assay development: providing initial assay development and assay validation.
• High Throughput Screening: automated miniaturized assay platform, by using our
existing 500+ assays or customers’ assays. The screening can be carried out by
using Key Organics’ Bionet libraries and/or customers’ libraries.
• Selectivity profiling: analyze the selectivity and potency of the lead compounds with 500+
drug targets.
• In vitro CYP450 inhibition assays using microsomes.
• In vitro biochemical hERG assays to predict the compounds safety.
• Cell based toxicity evaluations by detecting cell proliferation and apoptosis.
• Protein/expression evaluations by detecting protein expression or post-translational
modifications after cells treated with compounds.

Custom Synthesis

Can’t find what you are looking for? We can make it on a custom synthesis basis.

Quotations and the required compounds are delivered by chemists with proven track records succeeding with novel and difficult syntheses. Extensive computational chemistry expertise can tailor compounds to the desired site of action.

Competitive pricing coupled with sector leading quality and service, delivers unbeatable value for money.

Such projects may include:
• Synthesis of targeted organic compounds.
• Peptide and carbohydrate synthesis.

• Compounds for metabolite studies.

• Impurities for further study.
• Standards for comparison measurements.
• Synthesis of monomers and intermediates.
• Sourcing and extraction of natural products.
• Repeat syntheses on larger scale.

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Confidentiality
Key Organics' clients range from major multinationals, to biotechs, start-ups, and virtual companies. All have one thing in common - the need for absolute discretion and total confidentiality. Having provided outsourcing solutions for over 23 years, Key Organics has a proven track record of working in complete confidence under stringent non-disclosure agreements.

Quality
Every compound is rigorously quality assured by the in-house Analytical Department to meet or exceed the specifications of the individual client.

Biology Focus

Providing extensive services to Biologists / Biochemists is in keeping with Key Organics' drive to consistently listen to customers' changing needs, providing reliable solutions to their problems.

Biology/Screening Service

Key Organics - offers a wide range of biology/screening services to assist in the identification of lead compounds in any therapeutic area

Integration is the key

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